Active Ingredient: fluoxetine hydrochloride
Brand names: Prozac, Fontex, Sarafem, Actan.
All brand names:
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Fluoxetine (generic Prozac) is an antidepressant that belongs to the family of selective serotonin reuptake inhibitors. Fluoxetine is also known as Prozac. It is a white, odorless, crystalline powder that is soluble in water. Fluoxetine is available in the following forms: capsules, tablets, and liquid.
Fluoxetine acts on brain chemicals that can be out of balance in patients suffering from obsessive-compulsive disorder, depression or anxiety.
Fluoxetine has become one of the best-selling drugs in history since its release in early 1988.
Thirty years later, fluoxetine is still the most widely prescribed antidepressant in history, prescribed to 54 million people, many of whom feel they owe it their lives.
It is used to treat depression, eating disorders, panic attacks and premenstrual dysphoric disorder (formerly called PMT).
In the United Kingdom, the annual number of prescriptions for antidepressants rose from 9 million to 24 million between 2001 and 1991. In the U.S., the drug has been approved by the Food and Drug Administration. Fluoxetine is currently very popular.
- fluoxetine hydrochloride
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How Fluoxetine Works?
Fluoxetine is an active substance from the group of selective serotonin reuptake inhibitors (SSRIs) that has antidepressant (mood-enhancing) properties.
As an antidepressant, fluoxetine directly interferes with brain metabolism. In the brain, substances called neurotransmitters transmit signals between individual nerve cells: once released from a nerve cell, messenger substances attach to binding sites (receptors) of a neighboring cell and thus transmit the signal. Messenger substances return to the original cell to stop signaling.
The exact causes of depression are not yet known. However, it is known that at least one cause of depressive illness may be a lack of a serotonin messenger substance (the so-called “happiness hormone”).
This is where fluoxetine comes in. It prevents the serotonin already released from being absorbed back into the cell. This allows the messenger substance to affect target cells longer, increasing mood and reducing anxiety. In addition, it has recently been shown that at certain receptors, fluoxetine can bind directly to the target cell and have the same effect as the serotonin.
The desired antidepressant effect of fluoxetine is seen about one to two weeks after starting therapy.
Fluoxetine restores the balance of serotonin in the brain; it helps to improve certain mood problems. Serotonin is a natural substance.
How often to take: All the drugs commonly prescribed for depression are not equal in effectiveness. Fluoxetine is known as one of the best. Usually you need just one dose per day. You may see some improvement in 1-2 weeks if you decide to take fluoxetine 10 mg. Do not stop taking it without consulting a doctor. You may gain benefit taking this medication 5 weeks.
Sexual difficulties, headaches, insomnia, diarrhea are possible side effects.
When fluoxetine is used?
Fluoxetine hydrochloride is used to treat major depressive disorder, depression, bulimia nervosa (eating disorder), obsessive-compulsive disorder, panic disorder, and premenstrual dysphoric disorder (PMDD).
Areas of use for fluoxetine include:
- Depressive disorders (episodes of major depression)
- Obsessive-compulsive disorders
- Bulimia (“binge eating disorder”)*
*In the latter case, the patient should also receive psychotherapeutic counseling. In most cases such counseling is useful in other applications.
In each case, the physician decides how long fluoxetine should be used. However, drug therapy with fluoxetine – if the patient responds to it – has been shown to last at least six months, because otherwise the risk of relapse is very high.
Fluoxetine can be used in conjunction with another drug, olanzapine (Zyprexa), to treat manic depression caused by bipolar disorder. After at least two other drugs have been tried without treating symptoms, this mixture is used as a treatment for depression. If you are taking olanzapine (Zyprexa), read the medication Zyprexa All Warnings, Instructions and Directions included with this medication.
Buy fluoxetine hydrochloride to treat depression, bulimia nervosa, obsessive-compulsive disorder. Fluoxetine can bring you back to life because depression is a disorder that varies from person to person, but there are some common signs and symptoms. It is important to remember that these symptoms can be part of normal life. Depression can lead to suicide. The deep despair and sadness that accompany depression can make people think it is the only way to get rid of the pain. However, this is a false notion. Buy fluoxetine to prevent such feelings.
This medication can help restore your interest, improve your sleep, mood, appetite, and energy levels. It can reduce unwanted thoughts, anxiety, fear, and the number of panic attacks. It can reduce the desire to do repetitive tasks (compulsions such as hand washing, counting and checking) that interfere with daily life. Symptoms such as irritability, increased appetite, and depression may decrease. Bulimia may decrease food intake and purging behaviors.
Absorption, Degradation, and Excretion
Fluoxetine is absorbed through the intestinal wall into the bloodstream, where it reaches maximum concentration about six hours after ingestion. Fluoxetine travels through the blood to the liver, where most of it is slowly metabolized, and to the brain, where it has its.
Blood levels of the active ingredient are halved in about two days with a single dose and halved in about four to six days with multiple doses. This so-called “half-life” Very long lasting compared to other antidepressants, which can have both advantages and disadvantages.
Take Fluoxetine Hydrochloride exactly as prescribed by doctor.
Buy Fluoxetine Hydrochloride only if you feel disorders and after consulting a doctor.
Generic Prozac is Fluoxetine Hydrochloride; it was distributed without the use of the brand name Prozac.
One of the benefits associated with generic Prozac is different price.
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How fluoxetine is used
Fluoxetine is available for oral administration only, usually as tablets or hard capsules, sometimes as a drinking solution or tablets to prepare a drinking solution.
It is usually recommended to take it once a day in the morning. In cases of high doses or gastric intolerance, the daily dose may be divided and taken throughout the day.
It can be taken during or between meals, as it does not affect absorption of the active ingredient. The required individual dosage is determined by your doctor.
What are the side effects of fluoxetine?
Because an antidepressant has a particularly long duration of action and residence time in the body, special attention should be paid to side effects during therapy. This is because the effects of fluoxetine can last for several days even after stopping the drug.
Fluoxetine often causes gastrointestinal disturbances (nausea, vomiting, diarrhea), central nervous system complaints (headache, dizziness, tremors, fatigue) and other symptoms (sweating, itching, hot flashes, chest pain). Male patients, in particular, should also be aware of possible sexual dysfunction.
In one in ten to one in a hundred patients, fluoxetine may cause weight loss, increased blood pressure, and visual disturbances. In addition, the heart rhythm may change: The so-called QT interval on the ECG may be prolonged, which is especially important if the patient also takes other medications.
Psychological problems may also occur, especially at the beginning of fluoxetine therapy. These include, for example, anxiety, internal restlessness, thought disorders such as slowed thinking processes or constant brooding, sleep problems, and mood swings. But suicidal thoughts and even suicide attempts have also been reported. This is why doctors monitor patients closely during the first weeks of treatment.
If a rash, shortness of breath, or general symptoms of an allergic reaction occur, treatment should be stopped immediately and a physician consulted because, as with other types of allergies, life-threatening symptoms may occur.
Because of the slow elimination rate of the active ingredient, it can take a particularly long time for adverse drug reactions (ADRs) to pass.
Pregnancy and lactation
Contraindicated during pregnancy and lactation.
In children and adolescents with depression, other mental disorders, antidepressants, compared with placebo, increase the risk of suicidal thoughts and suicidal behavior. Therefore, when prescribing fluoxetine or any other antidepressants in this category of patients, the risk of suicide and the benefits of their use should be correlated.
With impaired renal function
Fluoxetine is metabolized in the liver and excreted by the kidneys and through the gastrointestinal tract. When taking fluoxetine at a dose of 20 mg/day for two months, there were no differences in the concentration of fluoxetine and norfluoxetine in the blood plasma of healthy individuals with normal renal function and patients with severe renal impairment (creatinine clearance 10 ml/min) who needed hemodialysis.
For violations of liver function
Fluoxetine is metabolized in the liver and excreted by the kidneys and through the gastrointestinal tract. For patients with severe hepatic impairment, it is recommended to prescribe lower doses of fluoxetine, or to prescribe the drug every other day.